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Table 2 Hydrophobicity parameters Rm w , S and φ o obtained for nabumetone on lipid films of various thicknesses, highlighting benchmark requirements and constraint

From: Engineering and validation of a novel lipid thin film for biomembrane modeling in lipophilicity determination of drugs and xenobiotics

Layer type* S Rm w φ o φ n R 2 S y,x
5% LP -3.48 2.43 0.70 0.35-0.70 5 0.986 0.056
5% LO -4.67 3.48 0.75 0.60-0.80 5 0.949 0.085
3.75% LO a -3.95 2.58 0.66 0.55-0.70 5 0.895 0.082
2.5% LO -3.14 1.94 0.62 0.50-0.70 5 0.974 0.040
1.25% LO b -2.33 1.05 0.45 0.25-0.60 5 0.981 0.047
  1. *LP = liquid paraffin, LO = leucaena oil,
  2. aStatistically similar to benchmark (LP, p > 0.05, 1-way ANOVA)
  3. bPlate development cycle time (for 7 cm path length and φ of 0.5) is 39 min, lower than the range 45-50 min for other film thicknesses investigated.