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Table 2 Hydrophobicity parameters Rm w , S and φ o obtained for nabumetone on lipid films of various thicknesses, highlighting benchmark requirements and constraint

From: Engineering and validation of a novel lipid thin film for biomembrane modeling in lipophilicity determination of drugs and xenobiotics

Layer type*

S

Rm w

φ o

φ

n

R 2

S y,x

5% LP

-3.48

2.43

0.70

0.35-0.70

5

0.986

0.056

5% LO

-4.67

3.48

0.75

0.60-0.80

5

0.949

0.085

3.75% LO a

-3.95

2.58

0.66

0.55-0.70

5

0.895

0.082

2.5% LO

-3.14

1.94

0.62

0.50-0.70

5

0.974

0.040

1.25% LO b

-2.33

1.05

0.45

0.25-0.60

5

0.981

0.047

  1. *LP = liquid paraffin, LO = leucaena oil,
  2. aStatistically similar to benchmark (LP, p > 0.05, 1-way ANOVA)
  3. bPlate development cycle time (for 7 cm path length and φ of 0.5) is 39 min, lower than the range 45-50 min for other film thicknesses investigated.
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Journal of Biological Engineering

ISSN: 1754-1611