Table 3 Basic and derived lipophilicity parameters for model compounds on 3 layer types.
Layer type | S | Rm w | φ o | φ | n | R 2 | S y,x |
|---|---|---|---|---|---|---|---|
ADBA | |||||||
LO | -8.84 | -0.646 | -0.073 | 0.003125-0.025 | 4 | 0.974 | 0.0141 |
LP | -5.99 | -4.85 | -0.081 | 0.0025-0.0254 | 4 | 0.806 | 0.0495 |
ODS | -1.41 | -0.102 | -0.073 | 0.025-0.40 | 5 | 0.915 | 0.0620 |
Naproxen | |||||||
LO | -6.32 | -0.459 | -0.073 | 0.003125-0.025 | 4 | 0.753 | 0.0350 |
LP | -5.42 | 0.610 | 0.11 | 0.0025-0.10 | 6 | 0.819 | 0.0959 |
ODS | -2.18 | 1.30 | 0.60 | 0.20-0.80 | 6 | 0.961 | 0.0944 |
Nabumetone | |||||||
LO | -3.95 | 2.58 | 0.66 | 0.55-0.70 | 5 | 0.895 | 0.0815 |
LP | -3.48 | 2.43 | 0.70 | 0.35-0.70 | 5 | 0.986 | 0.0556 |
ODS | -3.13 | 2.77 | 0.89 | 0.70-0.95 | 6 | 0.978 | 0.0438 |
Halofantrine | |||||||
LO | -8.13 | 8.40 | 1.03 | 0.925-0.99 | 5 | 0.738 | 0.120 |
LP | -6.54 | 6.76 | 1.03 | 0.90-1.0 | 5 | 0.864 | 0.102 |
ODS | -4.55 | 4.94 | 1.09 | 0.90-0.975 | 6 | 0.665 | 0.107 |