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Table 1 Dose-dependent inhibition of Aβ1–40 monomer aggregation and fibril growth in the presence of BSA a

From: Soluble aggregates of the amyloid-β peptide are trapped by serum albumin to enhance amyloid-β activation of endothelial cells

Reaction

Monomer Aggregation c

Fibril Growth d

(BSA:Aβb)

Lag Time

(fold increase)

Plateau

(% reduction)

Growth Rate

(% inhibition)

1:4

---

---

49 ± 11 *

1:1

1.9 ± 0.4

6 ± 6

61 ± 17 *

2:1

2.4 ± 0.6

34 ± 18

---

4:1

> 7 *

97 ± 2 *

---

5:1

---

---

80 ± 11 *

  1. a Parameters are expressed as mean ± SE, n = 3.
  2. b Aβ1–40 fibril concentrations are expressed in monomer units.
  3. c Monomer aggregation was measured as in Figure 1.
  4. d Fibril growth was measured as in Figure 2.
  5. * p < 0.05 compared to control.
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