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Table 1 Dose-dependent inhibition of Aβ1–40 monomer aggregation and fibril growth in the presence of BSA a

From: Soluble aggregates of the amyloid-β peptide are trapped by serum albumin to enhance amyloid-β activation of endothelial cells

Reaction Monomer Aggregation c Fibril Growth d
(BSA:Aβb) Lag Time
(fold increase)
Plateau
(% reduction)
Growth Rate
(% inhibition)
1:4 --- --- 49 ± 11 *
1:1 1.9 ± 0.4 6 ± 6 61 ± 17 *
2:1 2.4 ± 0.6 34 ± 18 ---
4:1 > 7 * 97 ± 2 * ---
5:1 --- --- 80 ± 11 *
  1. a Parameters are expressed as mean ± SE, n = 3.
  2. b1–40 fibril concentrations are expressed in monomer units.
  3. c Monomer aggregation was measured as in Figure 1.
  4. d Fibril growth was measured as in Figure 2.
  5. * p < 0.05 compared to control.