Bioresponsive matrices in drug delivery

Table 1 Stimuli-sensitive drug delivery.

Stimulus	Carrier type	Payload	Reference
pH	PPADK	Dexamethasone	[45]
	DMAEMA/HEMA	Paclitaxel	[3]
	PC/DAP liposomes	siRNA	[51]
Temperature	PNIPAm/PLGA	Paclitaxel	[36]
	MPPC/DPPC/HSPC/DSPEC-PEG-2000	Doxorubicin	[54]
	FA/PDMA/PNIPAm	Dipyridamole	[57]
Light	Cu chlorophyllin/PNIPAm	None reported	[60]
	Quinone-methide	Nile Red	[63]
	Au/meso porous silica	Paclitaxel	[61]
Ultrasound	Pluronic P105/N,N-diethylacrylamide	Doxorubicin	[66]
	DPPC:DPPE-PEG2000 liposomes	Calcein	[67]
Glucose	poly(methacrylic acid-g-ethylene glycol) with glucose oxidase, PNIPAm with phenylboronic acid	Insulin	[69–72]
	PNIPAm or carboxymethyl dextran with con. A	None reported	[73, 74]
Enzyme	PEG diacrylate/human neutrophil elastase-sensitive peptide	None reported	[75]
	Fibrin/β-nerve growth factor fusion proteins	β-nerve growth factor	[76]
	sPLA₂-degradable retinoid lipid pro-drug	Retinoid lipid pro-drug	[77]
Magnetic	Magnetite	Squalenoyl gemcitabine (SQdFdC)	[78]
	Poly[aniline-co-N-(1-one-butyric acid)] aniline (SPAnH)/iron oxide	Epirubicin	[79]
	Polylactide/nanocrystalline magnetite	Paclitaxel	[80]
	Egg-PC/maghemite/PAH/PSS	Calcein	[81]

ISSN: 1754-1611