Figure 6From: Fan-out in gene regulatory networksFan-out enhancement due to negative feedback. One of the mechanisms to enhance fan-out is to apply negative feedback on the output TF. This pushes the cut-off frequency away from the maximum desired operating frequency (ω max ), resulting in a larger value of fan-out: F NEG+ >F NEG- , where F NEG+ and F NEG- are the values of fan-out with and without negative feedback, respectively.Back to article page