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Figure 1 | Journal of Biological Engineering

Figure 1

From: Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells

Figure 1

Chemical structure of DMJ and its inhibition mechanism. (A) Comparison of the chemical and structural composition of DMJ to that of mannose. (B) Schematic diagram of the mechanism by which DMJ inhibits class I α1,2-mannosidase in the Golgi. α1,2-mannosidase I normally trims the α1,2-linked mannose on glycoproteins; however, DMJ inhibits α1,2-mannosidase I activity and thus restricts the oligosaccharide processing to high-mannose forms.

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Journal of Biological Engineering

ISSN: 1754-1611