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Figure 4 | Journal of Biological Engineering

Figure 4

From: Evolutionary principles and synthetic biology: avoiding a molecular tragedy of the commons with an engineered phage

Figure 4

Amplification on non-selective hosts. Amplification of T70 is 20-30 fold superior to that of T7E1 on a host lacking the K1 capsule (P < 0.001, t(6) = 7.4). The inferior amplification of T7E1 is attributed to a cost of encoding the endosialidase protein when there is no benefit of the protein. The growth period here spans ≈ 4 phage generations, and the media was LB agar with the non-capsulated host IJ1133. The bars span 2 standard errors, although the bars on T70 are small enough to be obscured by the triangle.

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