Figure 3

Nanocarriers for ocular siRNA delivery. This illustration shows four types of pegylated nanocarriers for ocular siRNA delivery: A) polymer, B) liposome, C) protein, D) dendrimer. The siRNA payload is typically entrapped, encapsulated or covalently bound to the nanocarrier interior to preserve its bioactivity, reduce non-specific cellular uptake and prevent undesirable activation of the innate immune system.