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Figure 8 | Journal of Biological Engineering

Figure 8

From: Hidden hysteresis – population dynamics can obscure gene network dynamics

Figure 8

Numerical solution showing the ratio of ON cells. The magenta and blue lines represent the OFF and ON phenotypes respectively. The solution assumes that the culture is started with a pure ON population, and cells switch to OFF over time. The numerical values for the growth rates and carrying capacities of the ON and OFF phenotypes were obtained from the model shown in Figure 7. The green line shows the size of the total population, while the beige curve starting at 1 shows the proportion of ON cells in the total culture. Panels A-C correspond to the three different dilution ratios tested. The final value of the ON fraction decreases as the dilution increases. In the 1:100 dilution case, the ON fraction is approximately 42%, while that in the 1:1 case is about 85%.

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