Figure 3
From: Engineering biodegradable and multifunctional peptide-based polymers for gene delivery
Synthesis of diblock HPMA copolymers containing multiple pendant peptides. RAFT polymerization of HPMA and PDSMA (molecule 1), and then chain-extension with HPMA and oligo(l-lysine) to form the second block (molecule 2). Disulfide exchange between the pyridyl disulfide on 2 and cysteine-functionalized oligo(l-histidine) peptides yields a diblock polymer with two bioactive peptides (molecule 3).