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Table 1 Characterization of lipid substitution on p [HPMA- co -K 10 ] copolymers

From: Engineering biodegradable and multifunctional peptide-based polymers for gene delivery

Polymer designation

Lys:Lipid mole ratio

Lipid/HPMA*

% Substituted Lys#

p(HPMA-co-K10-g-SA) (10:1)

10:1

0.35

14

p(HPMA-co-K10-g-SA) (20:1)

20:1

0.21

8.4

p(HPMA-co-K10-g-SA (40:1)

40:1

0.12

4.8

  1. *Based on NMR integration of lipid –CH2-CO (~ 2.4 ppm) and HPMA –CH(OH)-CH3 (~ 3.7 ppm).
  2. #Based on the theoretical mole ratio (~20% AhxK10 and 80% HPMA): 2.5 mole Lys/1 mole HPMA.
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Journal of Biological Engineering

ISSN: 1754-1611