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Figure 1 | Journal of Biological Engineering

Figure 1

From: Parameter-less approaches for interpreting dynamic cellular response

Figure 1

The observation of linear response waves. A) Schematic of activated signaling species, such as protein binding and gene expressions, with respect to time following formation and decay waves. Top panel represents a simple linear cascade with single wave. Bottom panel illustrates two linear waves superposed, as a consequence of an additional time-delay formation term. This may arise from feedback or crosstalk mechanisms. B) Quantitative dynamics of key molecules in insulin signaling pathway, showing similar dynamics to schematic in A). Figures adapted from[16]. C) Schematic of linear and switch-like relationship between transcription factor concentration and gene expressions.

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