Table 2 Variables and their definitions in the mathematical models
Symbol | Definition | Symbol | Definition |
|---|---|---|---|
u v | Blood velocity vector in vascular domain | c v | DOX concentration in vascular domain |
u i | Blood velocity vector in interstitial domain | c E | Extracellular DOX concentration |
P v | Vascular blood pressure | c I | Intracellular DOX concentration |
P i | Interstitial fluid pressure | R | Hypothetical downstream intermediate protein in apoptosis signalling cascade |
J F | Transmural fluid velocity, determined by Starling’s law | R 1 | Hypothetical protein responsible for triggering apoptosis |
J s | Transmural drug flux, determined by Kedem-Katchalsky equation | c t | Tumour cell density |