Skip to main content

Table 2 Variables and their definitions in the mathematical models

From: Towards an integrated systems-based modelling framework for drug transport and its effect on tumour cells

Symbol Definition Symbol Definition
u v Blood velocity vector in vascular domain c v DOX concentration in vascular domain
u i Blood velocity vector in interstitial domain c E Extracellular DOX concentration
P v Vascular blood pressure c I Intracellular DOX concentration
P i Interstitial fluid pressure R Hypothetical downstream intermediate protein in apoptosis signalling cascade
J F Transmural fluid velocity, determined by Starling’s law R 1 Hypothetical protein responsible for triggering apoptosis
J s Transmural drug flux, determined by Kedem-Katchalsky equation c t Tumour cell density