Figure 6

BMP-2 plasmid loaded electrospun scaffolds for bone tissue engineering. (A) In vitro release curve of three groups of scaffolds [56], Copyright 2007. Reproduced with permission from Elsevier. (B) Radiographs of nude mice tibias after 2 and 4 weeks of implantation of scaffolds. Bone fragment without implantation of any scaffold is denoted as control and white arrows identify bone defects [82], Copyright 2009. Reproduced with permission from Elsevier. (Group A: PLGA/HAp composite fiber with naked DNA coated outside, Group B: PLGA/HAp composite fiber with DNA-loaded chitosan nanoparticles coated outside, Group C: PLGA/HAp composite fiber with DNA-loaded chitosan nanoparticles encapsulated inside. The number indicates HAp contents in composite. X1: 0/100, X2: 5/95, X3: 10/90 (HAp/PLGA w/w%)).