Skip to main content
Fig. 2 | Journal of Biological Engineering

Fig. 2

From: Design and engineering of a transmissible antiviral defense

Fig. 2

Effect of initial vaccinations and reproductive parameters on dynamics of vaccine and helper. All bacteria ultimately become infected with helper, but protection by vaccine accrues only to the bacteria that (also) receive vaccine. Furthermore, vaccine can only be acquired before a cell is infected with helper, so cells infected with helper-only can never become protected. Thus we care most about the long term fraction of all cells infected with vaccine regardless of whether they are also infected with helper (thick dark red). a Using parameters from Table 4 in Appendix, and introducing only 100 initial vaccinations (as doubly-infected cells at time 0) the vaccine is vastly outpaced by helper by nearly 4 logs and is ineffective at protecting the population. Progressively higher numbers of initial vaccinations yield progressively better vaccine coverage [(b), (c)]. Panel d increases the reproductive output 10-fold for doubly-infected cells (b VM =7, b MV =0.06) but otherwise uses the same conditions as in (b): there is a substantial improvement in coverage. Both c and d result in most infected cells carrying vaccine. Thus improvement in reproductive parameters and high levels of ‘manual’ vaccination are different ways to substantially increase coverage. Equations used are given in (A1) with lethal virus omitted; parameter values were as in Table 4 in Appendix, except as indicated for (D). Initial vaccinations were added as H VMS at time 0

Back to article page