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Fig. 4 | Journal of Biological Engineering

Fig. 4

From: Exploiting the dynamic properties of covalent modification cycle for the design of synthetic analog biomolecular circuitry

Fig. 4

Computing the absolute value. a Block diagram of a circuit to compute the absolute value using a combination of operators. b Block diagram of a circuit to compute the absolute value using the threshold-hyperbolic and signal-transducing regimes from the covalent modification cycle. c Computation of absolute value. Black solid line: the input value. Green dashed-dot line: using combination of operators. Blue dashed line: using threshold-hyperbolic and signal-transducing regimes from the covalent modification cycle. (i) Input, u=±1 M, (ii) Input, u=±2 M. (iii) Input, u=±3 M. (iv) Input, u=±4 M. (v) Input, u=±5 M. (vi) Input, u=±6 M. d Comparison between ideal (Blue solid line) and simulated (Red dashed line) responses. (i) Threshold-hyperbolic response. (ii) Signal-transducing response

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