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Fig. 6 | Journal of Biological Engineering

Fig. 6

From: Strategies for using nanoprobes to perceive and treat cancer activity: a review

Fig. 6

a The dual imaging process of activatable magnetic nanoprobes (magnetic nanocrystals conjugated with activatable fluorogenic peptides, MNC-ActFP) for i) molecular detection of MT1-MMP anchored on invasive cancer cells by MR imaging and ii) sensitive recognition of the proteolytic activity of MT1-MMP by fluorescence imaging. Q = quencher, F = fluorescence dye. b In vivo MR (Upper) and NIR fluorescence (Lower) images of tumor-bearing mice at different time points after intravenous injection of MNC-ActFP. Red arrowheads in the MR images indicate the signal-enhanced sites of the tumor. c ΔR2/R2 nontreatment (line scatter) and NIR fluorescence intensity (bar graphs). d NIR fluorescence images (upper) and their intensity graph (lower) for excised tumors from tumor-bearing mice 1 h after intravenous injection of MNC-ActFP, MNC-ScrFP, or MNC-ActFP plus inhibitor. Reproduced with permission from ref. 67; Copyright 2011 Wiley-VCH

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