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Table 1 Percent inhibition of Aβ1–40 monomer aggregation observed in the presence of surface-coated NPsa,b

From: Influence of gold nanoparticle surface chemistry and diameter upon Alzheimer’s disease amyloid-β protein aggregation

NP type

[NP]

Surface Modification

Diameter

20 pM

100 pM

200 pM

Citrate

18 nm

4.3 ± 2.6

0.0 ± 0.0

19 ± 8*

PAH

18 nm

45 ± 4*

47 ± 5*

59 ± 9*

PAA

18 nm

97 ± 2*

99 ± 0*

95 ± 3*

PAA

8 nm

95 ± 3*

92 ± 4*

94 ± 1*

  1. *p < 0.001 compared to control
  2. aInhibition is expressed as plateau reduction, or the percentage of reduction in the equilibrium plateau compared to the control
  3. bParameters are expressed as mean ± SEM, n = 3–5