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Table 1 Bonding strategies of SDF-1α-loaded scaffolds

From: Delivery of stromal cell-derived factor 1α for in situ tissue regeneration

  Bonding strategy Features Applications (SM; LC; LE) References
Direct loading or adsorption Ease of operation; burst release; short release duration; poor loading efficiency hydroxyethyl methacrylate (HEMA) /hyaluronic acid (HA) hydrogels;
SDF-1α: 4 μg/ml
PCL and type B-gelatin;
SDF-1α:2.5 ~ 10 μg/ml
Immobilization through the formation of ionic complexes Extensive applicability; efficient dsorption; free of linker molecules; less dependent on surface properties; adjustable release rate; requires cytotoxic surfactants PGS (PEDA/heparin coacervate);
SDF-1α:8 μg/ml
SDF-1α:0.5 μg /ml
Immobilization through specific heparin-mediated interaction Anti-thrombogenicity; efficient adsorption; prevent enzymolysis; sustained release; complex operation 19%PLLA 5%PCL (w/v);
SDF-1α:0.5 μg /ml
StarPEG-heparin hydrogel;
SDF-1α:2.5 ~ 15 μg/ml;
Co-Cr plates;
SDF-1α:0.25 ~ 2 μg/ml
Particulate systems Sustained release; long release duration; multiple proteins load; complex operation Dex-GMA/gelatin microcapsules (PNIPAAm thermo gates);
SDF-1α:0.1 μg /ml
PLGA nanoparticles [27]
  1. Abbreviations: SM scaffold materials, LC loading concentration, LE loading efficiency