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Fig. 1 | Journal of Biological Engineering

Fig. 1

From: Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor

Fig. 1

a Schematic diagram of the MmfR binding mechanism. Binding of MmfR to DNA at the MARE represses gene transcription and therefore negates system output. In the presence of MMF ligand, an MmfR:MMF complex is formed which releases MmfR from the MARE and triggers gene transcription. b Schematic diagram of the methylenomycin gene cluster whereby fpm and apm represent the DNA binding motifs recognized by MmfR and MmyR proteins. The fpm controls the expression of mmfR, mmyR and mmfLHP genes while apm regulates the expression of the mmy biosynthetic genes

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