Table 1 Parameters description and estimated values
Parameter | Units | Estimated value (NBM, training set) | Estimated value (BM, training set) | Estimated value (BM, via simultaneous fitting on all circuits) |
|---|---|---|---|---|
αX1 | AUR cell−1 min−1 | 14.63 (3%) | 36.17 (7%) | 24.33 (4%) |
KX1 | nM | 4.16 (9%) | 5.39 (9%) | 6.71 (6%) |
ηX1 | -* | 1.42 (3%) | 1.51 (2%) | 1.19 (2%) |
δX1 | AUR cell−1 min−1 | 0.14 (3%) | 0.16 (3%) | 0.2 (2%) |
αX2 | AUR cell−1 min−1 | 9.06 (1%) | 26.76 (3%) | 20.36 (3%) |
KX2 | nM | 15.06 (7%) | 17.26 (6%) | 31.39 (7%) |
ηX2 | – | 1.24 (3%) | 1.25 (3%) | 0.97 (2%) |
δX2 | AUR cell−1 min−1 | 0.14 (2%) | 0.26 (5%) | 0.18 (5%) |
αX3 | AUR cell−1 min−1 | 15.81 (3%) | 36.9 (5%) | 35.67 (5%) |
KX3 | nM | 4.37 (16%) | 7.64 (17%) | 8.9 (14%) |
ηX3 | – | 1.45 (6%) | 1.41 (6%) | 1.34 (6%) |
δX3 | AUR cell−1 min−1 | 0.16 (5%) | 0.18 (3%) | 0.19 (2%) |
αXrep | AUR cell−1 min−1 | 2.85 (1%) | 4.6 (4%) | 8.22 (2%) |
KXrep | nM | 6.67 (12%) | 5.26 (11%) | 1.86 (5%) |
ηXrep | – | 1.32 (12%) | 1.21 (9%) | 0.86 (2%) |
δXrep | AUR cell−1 min−1 | 0.13 (17%) | 0.22 (14%) | 0.09 (15%) |
αT | AUR cell−1 min−1 | 3.1 (1%) | 3.45 (3%) | 4.56 (2%) |
KT | AUR cell−1 | 6.47 (5%) | 15.6 (7%) | 6.92 (2%) |
ηT | – | 1.59 (7%) | 8.28 (31%) | 2.57 (2%) |
δT | AUR cell−1 min−1 | 0.03 (19%) | 0.22 (3%) | 0.21 (2%) |
αL | AUR cell−1 min−1 | 0.63 (6%) | 0.56 (9%) | 0.76 (2%) |
KL | AUR cell−1 | 56.39 (17%) | 52.13 (22%) | 34.92 (2%) |
ηL | – | 1.91 (16%) | 1.93 (42%) | 1.93 (3%) |
δL | AUR cell−1 min−1 | 0.11 (26%) | 0.22 (19%) | 0.22 (3%) |
ΣXλ | – | NA* | 0.2 (8%) | 0.36 (2%) |
ΣXlac | – | NA | 1 (6%) | 0.56 (2%) |
ΣXtet | – | NA | 0.07 (23%) | 0.12 (11%) |
JRFP | AUR −1 cell min | NA | 0.04 (3%) | 0.04 (3%) |
Jtet | AUR −1 cell min | NA | 0.07 (15%) | 0.31 (2%) |
Jlac | AUR −1 cell min | NA | 0.01 (13%) | 0.01 (7%) |
Sm | AUG cell−1 min−1 | NA | 1.75 (2%) | 1.75 (2%) |