Fig. 10

In vivo transplantation: (a) H&E staining of transplanted scaffolds showing that the transplanted scaffolds contained a large number of normal red blood cells (arrow) and numerous islet cells (INS-1E) (arrow head). b The integrity of the pancreatic capsule (arrow) was completely retained. c H&E staining of the scaffolds before transplantation showing a honeycomb structure in the scaffold (arrow). d H&E staining of the transplanted scaffolds after 1 week showing thrombosis (#) in the scaffolds. e Blood glucose monitoring results showed that blood glucose levels were clearly lower after the transplantation of the recellularized pancreas or the direct injection of islet cells via the portal vein. The transplanted recellularized pancreas maintained normal blood glucose levels for 7 days