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Fig. 3 | Journal of Biological Engineering

Fig. 3

From: Auxotrophy to Xeno-DNA: an exploration of combinatorial mechanisms for a high-fidelity biosafety system for synthetic biology applications

Fig. 3

Biosafety defense level. Assuming that physical containment fails, and the engineered bacteria escape their designated environment (e.g. a bioreactor), there are two ways possibly leading to a total biosafety system collapse. A biosafety collapse happens once either HGT or VGT (reproduction) occurs. Therefore, transfer of genetic information from the engineered cell to a wildtype cell can only occur if all mechanisms preventing either HGT or VGT, respectively, fail

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Journal of Biological Engineering

ISSN: 1754-1611