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Fig. 1 | Journal of Biological Engineering

Fig. 1

From: In vitro culture expansion impairs chondrogenic differentiation and the therapeutic effect of mesenchymal stem cells by regulating the unfolded protein response

Fig. 1

Microarray and quantitative RT-PCR analysis of P0 and P3 BMSCs. a Differential gene expression in P3 BMSCs compared with P0 BMSCs. b Pathway enrichment analyses of differentially expressed genes between P3 and P0 BMSCs. c Hierarchical cluster analysis of UPR-related genes showed differential expression between P3 and P0 BMSCs. The genes connected by the lines indicate the clustered genes based on Hierarchical cluster analysis. d Expression of the three critical genes (ATF4, ATF6, and XBP1) of UPR was measured by quantitative RT-PCR analysis in P0 and P3 BMSCs. These data were normalized to GAPDH. The values were means ± S.D.; * indicate P < 0.05, ** indicate P < 0.01, *** indicate P < 0.001

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