Fig. 5

Melanosome migration in the zebrafish RPE due to light- and dark-adaptation as seen with photothermal optical coherence tomography (PT-OCT). a-b OCT cross-sectional images of the zebrafish retina with (c-d) co-registered PT-OCT images showing melanin distribution due to light- or dark-adaptation of the zebrafish, with (e-f) corresponding histology sections. White arrowheads indicate different structures where melanin is present [co-registered between images (a) and (c), and (b) and (d), approximate location for images (e) and (f)]. Scale bar: 50 μm for OCT and PT-OCT images, 25 μm for histology. INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; PR, photoreceptors; ISe, photoreceptor inner segment ellipsoid zone; OS, photoreceptor outer segment. Reprinted from [122] under creative commons license