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Fig. 7 | Journal of Biological Engineering

Fig. 7

From: CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration

Fig. 7

HIF-1α-NOTCH1 pathway activation is essential for CD24+ NP cells maintenance. a-b Western blot analysis of JAGGED-1, NOTCH1 and HES-1 expression in CD24+, CD24 and unsorted NP cells. (c) Quantification analysis of JAGGED-1, NOTCH1 and HES-1 mRNA expression in CD24+, CD24 and unsorted NP cells. d-e Fluorescence activated cell sorting analysis of the percentage of CD24+ NP cells after Hif-1α or Vhl knock down with or without DAPT and JAGGED-1 stimulation. *P < 0.05, **P < 0.01, ***P < 0.001. P-values were analyzed by one-way ANOVA

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