From: Follicle development as an orchestrated signaling network in a 3D organoid
Oocyte-Secreted Factors | |
---|---|
BMP-15, GDF-9 | Promotes granulosa proliferation and theca layer development [13, 20,21,22,23,24, 27, 35, 55] |
FGF-2, FGF-8 | Promotes granulosa cell proliferation and survival [37, 39,40,41,42, 44] |
Granulosa Cell-Secreted Factors | |
 Activin, BMP-2, BMP-5 | |
 MIF, EGF, FGF-8 | |
 FGF-2 | |
 Aquaporin, Versican | |
Theca Cell-Secreted Factors | |
 BMP-7 | Promotes granulosa cell proliferation [45] |
 FGF-7 | Promotes theca layer development [74] |