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Table 1 Follicle-secreted factors and their functions, classified by secreting cell type

From: Follicle development as an orchestrated signaling network in a 3D organoid

Oocyte-Secreted Factors
BMP-15, GDF-9 Promotes granulosa proliferation and theca layer development [13, 20,21,22,23,24, 27, 35, 55]
FGF-2, FGF-8 Promotes granulosa cell proliferation and survival [37, 39,40,41,42, 44]
Granulosa Cell-Secreted Factors
 Activin, BMP-2, BMP-5 Promote granulosa cell proliferation [29, 57,58,59,60]
 MIF, EGF, FGF-8 Promote theca layer development [17, 27, 55, 56]
 FGF-2 Promote theca layer angiogenesis [18, 76]
 Aquaporin, Versican Facilitate antrum development [53, 78, 80]
Theca Cell-Secreted Factors
 BMP-7 Promotes granulosa cell proliferation [45]
 FGF-7 Promotes theca layer development [74]