Fig. 6

Using SACE_5754 pathway to improve erythromycin production. a Er-A production in A226 and its derivatives. b Er-A production in S. erythraea WB and its derivatives. Mean values of three replicate are shown, with the standard deviation indicated by error bars. *p < 0.05, **p < 0.01, ***p < 0.001, ns, no significant (relative to A226 or WB). c Time course of Er-A production of WB and WB∆SACE_5754 /pIB139–0388-6149 in a 5 L fermenter