Fig. 1
From: Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy
Receptor-based inhibitors. a An engineered multivalent ligand inhibits the CT B subunit from interacting with GM1 on the host cell membrane. b A small peptide based on the binding site of the integrin CD11a targeted by LtxA inhibits toxin binding to the receptor. c A peptide inhibitor based on the CRAC motif of LtxA shields cholesterol in the host membrane. d A polyvalent inhibitor blocks LF and EF from interacting with membrane-bound PA