Fig. 2From: Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategyDominant-negative inhibitors. a WT toxin in solution forms an oligomer on the host cell surface. After a conformational change, the transmembrane domains assemble a channel in the plasma membrane. b Incorporation of a dominant-negative protein with WT toxin prevents cytotoxic activity by inhibiting the assembly of a functional channelBack to article page