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Table 1 The cytotoxic concentration of hepatotoxic drugs in CHIR-treated HepaRG cells

From: Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity

Hepatotoxic drugs Untreated control 9 μM CHIR
IC50 95% confidence interval IC50 95% confidence interval
Tamoxifen (μM) 51.0 34.3–67.7 35.2 25.5–44.8
Isoniazid (μM) 13.3 12.5–14.1 13.2 12.1–14.3
Bromobenzene (μM) 12.5 9.3–15.7 0.8* 0.4–1.2
Acetaminophen (mM) 10.0 9.7–10.3 4.2* 3.2–5.2
  1. P-values indicate significant differences between the IC50 values of hepatotoxic drugs after CHIR treatment. * P < 0.05