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Table 1 The cytotoxic concentration of hepatotoxic drugs in CHIR-treated HepaRG cells

From: Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity

Hepatotoxic drugs

Untreated control

9 μM CHIR

IC50

95% confidence interval

IC50

95% confidence interval

Tamoxifen (μM)

51.0

34.3–67.7

35.2

25.5–44.8

Isoniazid (μM)

13.3

12.5–14.1

13.2

12.1–14.3

Bromobenzene (μM)

12.5

9.3–15.7

0.8*

0.4–1.2

Acetaminophen (mM)

10.0

9.7–10.3

4.2*

3.2–5.2

  1. P-values indicate significant differences between the IC50 values of hepatotoxic drugs after CHIR treatment. * P < 0.05
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Journal of Biological Engineering

ISSN: 1754-1611