Skip to main content

Table 1 Protein expression of selected transporters in both monolayer culture systems measured at day 10 of culture and in fresh crypts/villi. Concentrations (C) are reported in pmol/mg membrane fraction protein; C > 5 (++++); 5 > C > 3 (+++); 3 > C > 0.5 (++); 0.5 > C (+)

From: Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking

Protein

Grad X-linked Scaffold

Conventional Scaffold

Fresh Crypts/ Villi

P-gp

++++

++++

++++

BCRP

++++

+

++++

MRP1

+

+

+

MRP2

+++

++

+++

MRP3

++

++

++

OCT3

++

++

++

Na K ATPase

++++

++++

++++

GGTP

++++

++++

++++