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Table 1 Protein expression of selected transporters in both monolayer culture systems measured at day 10 of culture and in fresh crypts/villi. Concentrations (C) are reported in pmol/mg membrane fraction protein; C > 5 (++++); 5 > C > 3 (+++); 3 > C > 0.5 (++); 0.5 > C (+)

From: Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking

Protein Grad X-linked Scaffold Conventional Scaffold Fresh Crypts/ Villi
P-gp ++++ ++++ ++++
BCRP ++++ + ++++
MRP1 + + +
MRP2 +++ ++ +++
MRP3 ++ ++ ++
OCT3 ++ ++ ++
Na K ATPase ++++ ++++ ++++
GGTP ++++ ++++ ++++