Novel biomanufacturing platform for large-scale and high-quality human T cells production

Table 3 Cytokine production by T cells expanded in stirred-tank bioreactor

Data source	Cytokines secretion^a	Day -4		Day 0		Day 4
Data source	Cytokines secretion^a	CD4⁺	CD8⁺	CD4⁺	CD8⁺	CD4⁺	CD8⁺
This study^b	IFN-γ	46.2–54.2	50.9–62.0	15.6–20.8	20.3–34.8	21.1–31.1	39.8–50.9
	IL-2	64.9–76.7	19.8–39.5	79.8–95.6	77.2–93.8	75.7–95.9	74.5–96.1
	IL-4	4.6–6.5	1.7–3.5	4.2–8.7	10.2–19.9	6.0–9.1	5.2–8.2
Literature	IFN-γ	17–23 [64] 6.7–38.9 [65]	27–37 [64] 20–58.4 [65]	N/A		23-47^b [66] 15-41^d [67]	42-72^b [66] 4–42 [68] 10-41^d [67]
	IL-2	60 [64]	25–35 [64]			53-78^d [67]	49-97^d [67]
	IL-4	0.2–4.9 [65]	0.1–1.6 [65]			19-47^c [66]	0-2^b [66]

ISSN: 1754-1611