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Table 3 Cytokine production by T cells expanded in stirred-tank bioreactor

From: Novel biomanufacturing platform for large-scale and high-quality human T cells production

Data source Cytokines secretiona Day -4 Day 0 Day 4
CD4+ CD8+ CD4+ CD8+ CD4+ CD8+
This studyb IFN-γ 46.2–54.2 50.9–62.0 15.6–20.8 20.3–34.8 21.1–31.1 39.8–50.9
IL-2 64.9–76.7 19.8–39.5 79.8–95.6 77.2–93.8 75.7–95.9 74.5–96.1
IL-4 4.6–6.5 1.7–3.5 4.2–8.7 10.2–19.9 6.0–9.1 5.2–8.2
Literature IFN-γ 17–23 [64]
6.7–38.9 [65]
27–37 [64]
20–58.4 [65]
N/A 23-47b [66]
15-41d [67]
42-72b [66]
4–42 [68]
10-41d [67]
IL-2 60 [64] 25–35 [64] 53-78d [67] 49-97d [67]
IL-4 0.2–4.9 [65] 0.1–1.6 [65] 19-47c [66] 0-2b [66]
  1. Notes
  2. aAll data are presented as mean ± standard error of the mean (SEM).
  3. bData were collected using the T cells isolated from 3 donors.
  4. cData were collected from a 21-day culture.
  5. dData were collected from a 14-day culture.