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Fig. 2 | Journal of Biological Engineering

Fig. 2

From: Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of sirt6

Fig. 2

High expression of PVT1 and low expression of sirt6 in synovial tissues of RA rats. a, the PVT1 expression in synovial tissues of rats in the control and RA groups determined by RT-qPCR; *p < 0.05 vs. the control group; b, the sirt6 expression in synovial tissues of rats in the control and RA groups quantified by immunofluorescence (× 200); c, a bar chart showing the sirt6 expression in synovial tissue of rats in the control and RA groups; *p < 0.05 vs. the control group; the control group = 10, the RA group = 12. The experiment was repeated 3 times to obtain the mean values; the gene expression levels and the fluorescence values were presented as mean ± standard derivation; independent t-test was performed for comparison between two groups. PVT1, long non-coding RNA plasmacytoma variant translocation 1; Sirt6, sirtuin 6; RA, rheumatoid arthritis; RT-qPCR, reverse transcription quantitative polymerase chain reaction

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Journal of Biological Engineering

ISSN: 1754-1611