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Fig. 9 | Journal of Biological Engineering

Fig. 9

From: Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of sirt6

Fig. 9

PVT1 could recruit DNA methyltransferases (DNMT1, DNMT3A and DNMT3B) to the sirt6 promoter region, thereby inhibiting the transcription of sirt6. With the downregulated expression of sirt6, the RA-FLS apoptosis was promoted while proliferation and invasion were enhanced. PVT1, long non-coding RNA plasmacytoma variant translocation 1; Sirt6, sirtuin 6; RA-FLS, rheumatoid arthritis fibroblast-like synoviocyte; DNMT1, DNA methyltransferase 1; DNMT3A, DNA methyltransferase 3A; DNMT3B, DNA methyltransferase 3B

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Journal of Biological Engineering

ISSN: 1754-1611