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Fig. 6 | Journal of Biological Engineering

Fig. 6

From: Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy

Fig. 6

Tumor therapeutic effects and intra-tumor distribution of therapeutic proteins. a BALB/c nude mice bearing SMMC-7721 tumors were intravenously injected with PBS, EcN, EcN (p53), EcN (Tum-5), or EcN (Tum 5-p53) weekly. The tumor volumes of the mice in each group (n = 6) were measured from the beginning of treatment. b At the end of the treatment, the mice were sacrificed and tumor tissues were excised and weighed. SMMC-7721 tumors were significantly inhibited by EcN (Tum-5), EcN (p53), EcN (Tum 5-p53) compared with the PBS or EcN group. c Identification of the distribution of Tum 5-p53 protein in tumor tissues by immunohistochemistry and H&E staining of tumor tissues (200×)

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Journal of Biological Engineering

ISSN: 1754-1611