Fig. 8

In vivo toxicity assay. BALB/c nude mice were weekly treated with PBS, EcN, EcN (p53), EcN (Tum-5), and EcN (Tum 5-p53). The weights of the mice were recorded every 2 days (a). At the end of the treatment, the livers, spleens, and kidneys of five mice were excised and weighed (b). Histology of liver, spleen, kidney, lung, and heart extracted from the mice (c)