Fig. 5

Co-deletion of SUN1 and SUN2 in MSCs disrupts β-catenin association with the nucleoskeleton. SUN1 and SUN2 were depleted via siRNA (siSUN) (a, b) siSUN decreased β-catenin-nucleoskeleton (Nsk) association and nuclear β-catenin level, as relative to the control (siCtrl). c, d In siSUN-treated cells, nesprin-2 and β-catenin were primarily located outside the nucleus; however, they were inside the nucleus in control siCtrl cells (white arrows). *: p < 0.05, ***: p < 0.001. Adapted and reprinted with permission from [46]