Fig. 6From: The LINC complex, mechanotransduction, and mesenchymal stem cell function and fateThe LINC complex connection to actin cytoskeleton is necessary for low-magnitude signal-induced suppression of MSC adipogenesis. a Schematic of the LINC complex. b,c Decoupling the LINC complex via silencing SUN with siRNA (siSUN) or overexpressing dominant negative KASH (DNKASH) in MSCs disrupted low-magnitude signal (LMS)-induced focal adhesion kinase (FAK) activation. d, e In siSUN treated cells, the LMS inhibition of adipogenesis is impaired, as assessed by adipogenic markers, adiponectin (APN) and AP-2. *: p < 0.05; ¥: p < 0.01; †: p < 0.001. Adapted and reprinted with permission from [48]Back to article page