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Fig. 6 | Journal of Biological Engineering

Fig. 6

From: The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate

Fig. 6

The LINC complex connection to actin cytoskeleton is necessary for low-magnitude signal-induced suppression of MSC adipogenesis. a Schematic of the LINC complex. b,c Decoupling the LINC complex via silencing SUN with siRNA (siSUN) or overexpressing dominant negative KASH (DNKASH) in MSCs disrupted low-magnitude signal (LMS)-induced focal adhesion kinase (FAK) activation. d, e In siSUN treated cells, the LMS inhibition of adipogenesis is impaired, as assessed by adipogenic markers, adiponectin (APN) and AP-2. *: p < 0.05; ¥: p < 0.01; †: p < 0.001. Adapted and reprinted with permission from [48]

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