From: Electrospun nanofibers for the fabrication of engineered vascular grafts
General Properties Of Scaffolds | Challenges | References |
---|---|---|
Biocompatibility | • Non-controlling degradation of biodegradable polymers in vivo | |
• The toxicity of products produced by the degradation of biocompatible polymers | ||
• Low cell seeding efficiency | ||
Mechanical Properties proper for tissue | • Scaffolding design with mechanical properties proportional to tissue | |
• Mechanical integrity | ||
• Protect cells against tensile and pressing forces | ||
Biodegradability | • The completion of the tissue healing is dependent on the rate of biodegradation | |
• At least toxicity and inflammation | ||
• Transmit the tissue growth conduction signals and differentiation | ||
• Cell migration | ||
• Pore size and porosity proportional to the tissue | ||
Porous interconnectivity | • At least toxicity and inflammation | |
• Transmit the tissue growth conduction signals and differentiation | ||
• Pore size and porosity proportional to the tissue | ||
• The possibility of exchanging gases, nutrients and growth factors and waste materials | ||
• Cell migration | ||
Chemical surface and topography | • Cell-cell interactions and cell adhesion, controlling cell function |