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Table 2 General properties for scaffolds and challenges

From: Electrospun nanofibers for the fabrication of engineered vascular grafts

General Properties Of ScaffoldsChallengesReferences
Biocompatibility• Non-controlling degradation of biodegradable polymers in vivo[103, 104]
• The toxicity of products produced by the degradation of biocompatible polymers
• Low cell seeding efficiency
Mechanical Properties proper for tissue• Scaffolding design with mechanical properties proportional to tissue[29, 38]
• Mechanical integrity
• Protect cells against tensile and pressing forces
Biodegradability• The completion of the tissue healing is dependent on the rate of biodegradation[105, 106]
• At least toxicity and inflammation
• Transmit the tissue growth conduction signals and differentiation
• Cell migration
• Pore size and porosity proportional to the tissue
Porous interconnectivity• At least toxicity and inflammation[105, 106]
• Transmit the tissue growth conduction signals and differentiation
• Pore size and porosity proportional to the tissue
• The possibility of exchanging gases, nutrients and growth factors and waste materials
• Cell migration
Chemical surface and topography• Cell-cell interactions and cell adhesion, controlling cell function[91, 107]