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Table 2 General properties for scaffolds and challenges

From: Electrospun nanofibers for the fabrication of engineered vascular grafts

General Properties Of Scaffolds

Challenges

References

Biocompatibility

• Non-controlling degradation of biodegradable polymers in vivo

[103, 104]

• The toxicity of products produced by the degradation of biocompatible polymers

• Low cell seeding efficiency

Mechanical Properties proper for tissue

• Scaffolding design with mechanical properties proportional to tissue

[29, 38]

• Mechanical integrity

• Protect cells against tensile and pressing forces

Biodegradability

• The completion of the tissue healing is dependent on the rate of biodegradation

[105, 106]

• At least toxicity and inflammation

• Transmit the tissue growth conduction signals and differentiation

• Cell migration

• Pore size and porosity proportional to the tissue

Porous interconnectivity

• At least toxicity and inflammation

[105, 106]

• Transmit the tissue growth conduction signals and differentiation

• Pore size and porosity proportional to the tissue

• The possibility of exchanging gases, nutrients and growth factors and waste materials

• Cell migration

Chemical surface and topography

• Cell-cell interactions and cell adhesion, controlling cell function

[91, 107]