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Table 1 Possible ranges of parameter values we used in our models

From: Computational analysis of viable parameter regions in models of synthetic biological systems

Parameter

Span

Unit

Transcription

10−2 - 50

h−1

Translation

10−2 - 50

h−1

Protein production

10−1 - 50

h−1

Protein degradation

10−3 - 50

h−1

mRNA degradation

10−1 - 100

h−1

Dissociation constant

10−2 - 250

nM

Michaelis constant

10−2 - 250

nM

Protease concentration

10 - 1000

nM

Dilution rate

0.6

h−1

Hill coefficient

1 - 5

-

Reaction volume (VR·NA)

1

nM−1

  1. Values obtained from [40, 45, 46] are a rough estimate of real kinetic rates for prokaryotes and eukaryotes combined. Nevertheless, we excluded the possibility of some extreme cases, like extremely long-lived or unstable proteins. VR describes reaction space volume and NA Avogadro constant.