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Fig. 2 | Journal of Biological Engineering

Fig. 2

From: Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury

Fig. 2

Schematic diagram of fibrin polymerization. α chains are in blue, β chains are in green, and γ chains are in red. aC domains are in gray. a Schematic diagram of fibrinogen monomer. b The catalytic action of thrombin exposes knobs A on the α chains N-terminal and knobs B on the β chains N-terminal. c Knobs A binds to holes a, knobs B binds to holes b, and αC domains bind to αC domains on adjacent molecules, Protofibrils finally form a branched 3D network gel structure through longitudinal extension and associate laterally. Reprinted with permission from [17]

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