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Table 1 Fibrin combined with natural polymers as a scaffold in tissue engineering

From: Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury

Composite material Fabrication methodology Architecture Enhanced performance Achievements References
Alginate 3D bioprinting Hollow gel tube-like structure, the inner layer of alginate, and the outer layer of fibrin Long-term cell viability Construction of artificial arteries and veins [36]
Cell adhesion
Chitosan Mix Fibrin hydrogels embedded with Sonic hedgehog (SHH)-loaded chitosan Delay the release of SHH, Promote spinal cord regeneration [37]
Nerve regeneration
Recovery of motor function,
Reduce tissue cavities
Collagen Fill conduits with fibrin hydrogels Collagen conduits filled with fibrin hydrogels The intensity of scaffold, Nerve conduits for peripheral nerve regeneration [38]
Culture autologous adipose-derived mesenchymal stem cells (ADMSCs) Expression of protein GAP-43
Axon regeneration
Fibronectin Mix Injectable forms of fibrin and fibronectin hydrogels Integrate with damaged spinal cord tissue, Injectable materials to fill cavities in the spinal cord [39]
Axon growth
Gelatin Mix Bone matrix gelatin mixed fibrin acts as a cell culture substrate Biocompatibility As a scaffold in cartilage tissue engineering [40]
Production of collagen II and aggrecan
Hyaluronic acid 3D bioprinting Core-shell structure, Neuronal cells and Schwann cells are respectively located in the core and shell Neurogenesis, Biomimetic nerve fibers with a bionic tubular myelin sheath [41]
Myelin maturation,
Coexistence of Schwann cells and neurons
Albumin Mix Albumin fibrin hydrogels embedded in the ferromagnetic fiber network Extracellular matrix deposition Scaffold for bone tissue engineering [42]