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Table 2 Fibrin combined with synthetic polymers as a scaffold in tissue engineering

From: Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury

Composite material Fabrication methodology Architecture Enhanced performance Achievements References
Poly (DL-lactic-co-glycolic acid) (PLGA) Electrospray for PLGA microspheres, Aligned fibrin hydrogels loaded with PLGA microspheres, Reduce the initial burst release of drugs Promote spinal cord regeneration [43]
Electrospinning for aligned fibrin hydrogels Stem cells extend along the long axis of the aligned hydrogels
PLGA microspheres contain drugs
Culture stem cells
Poly(L-lactide) (PLLA) Vacuum deposition Fibrin deposits on the microporous walls of PLLA scaffolds Increase elastic modulus Promote the early regeneration of bone and cartilage tissue [44]
Cell adhesion
Polylactic Acid (PLA) Melt-spun for PLA fibers Fibrin hydrogels contain square PLA fibers Structural support Biomaterials for cardiovascular tissue engineering [45]
Culture human coronary artery smooth muscle cells
(HCASMC)
Polyethylene Glycol (PEG) Mix 3D Hydrogels Neurites outgrowth Biomaterials for peripheral nerve regeneration [46]
Culture dorsal root ganglion (DRG) cells Control cells invasion characteristics
Polypropylene fumarate/ tricalcium phosphate (PPF/TCP) Mold method for PPF/TCP, scaffolds, Porous cylinder structure Bone growth Biomaterials for Bone tissue engineering [47]
Fibrin hydrogels were pipetted into the scaffolds Culture human gingival fibroblasts (HGFs)
Multiwall carbon nanotube/polyurethane (MWCNT/PU) Electrospinning for MWCNT/PU fiber, fiber fragments were incorporated into hydrogels 3D hydrogels with porous structure, Conductivity, Promote spinal cord regeneration [48]
Culture endometrial stem cells (hEnSCs) Hydrophilicity,
Hydrogels stiffness,
Reduced degradation rate
Cell adhesion and proliferation