From: Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury
Composite material | Fabrication methodology | Architecture | Enhanced performance | Achievements | References |
---|---|---|---|---|---|
Poly (DL-lactic-co-glycolic acid) (PLGA) | Electrospray for PLGA microspheres, | Aligned fibrin hydrogels loaded with PLGA microspheres, | Reduce the initial burst release of drugs | Promote spinal cord regeneration | [43] |
Electrospinning for aligned fibrin hydrogels | Stem cells extend along the long axis of the aligned hydrogels | ||||
PLGA microspheres contain drugs | |||||
Culture stem cells | |||||
Poly(L-lactide) (PLLA) | Vacuum deposition | Fibrin deposits on the microporous walls of PLLA scaffolds | Increase elastic modulus | Promote the early regeneration of bone and cartilage tissue | [44] |
Cell adhesion | |||||
Polylactic Acid (PLA) | Melt-spun for PLA fibers | Fibrin hydrogels contain square PLA fibers | Structural support | Biomaterials for cardiovascular tissue engineering | [45] |
Culture human coronary artery smooth muscle cells | |||||
(HCASMC) | |||||
Polyethylene Glycol (PEG) | Mix | 3D Hydrogels | Neurites outgrowth | Biomaterials for peripheral nerve regeneration | [46] |
Culture dorsal root ganglion (DRG) cells | Control cells invasion characteristics | ||||
Polypropylene fumarate/ tricalcium phosphate (PPF/TCP) | Mold method for PPF/TCP, scaffolds, | Porous cylinder structure | Bone growth | Biomaterials for Bone tissue engineering | [47] |
Fibrin hydrogels were pipetted into the scaffolds | Culture human gingival fibroblasts (HGFs) | ||||
Multiwall carbon nanotube/polyurethane (MWCNT/PU) | Electrospinning for MWCNT/PU fiber, fiber fragments were incorporated into hydrogels | 3D hydrogels with porous structure, | Conductivity, | Promote spinal cord regeneration | [48] |
Culture endometrial stem cells (hEnSCs) | Hydrophilicity, | ||||
Hydrogels stiffness, | |||||
Reduced degradation rate | |||||
Cell adhesion and proliferation |