Skip to main content

Table 2 Fibrin combined with synthetic polymers as a scaffold in tissue engineering

From: Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury

Composite material

Fabrication methodology

Architecture

Enhanced performance

Achievements

References

Poly (DL-lactic-co-glycolic acid) (PLGA)

Electrospray for PLGA microspheres,

Aligned fibrin hydrogels loaded with PLGA microspheres,

Reduce the initial burst release of drugs

Promote spinal cord regeneration

[43]

Electrospinning for aligned fibrin hydrogels

Stem cells extend along the long axis of the aligned hydrogels

PLGA microspheres contain drugs

Culture stem cells

Poly(L-lactide) (PLLA)

Vacuum deposition

Fibrin deposits on the microporous walls of PLLA scaffolds

Increase elastic modulus

Promote the early regeneration of bone and cartilage tissue

[44]

Cell adhesion

Polylactic Acid (PLA)

Melt-spun for PLA fibers

Fibrin hydrogels contain square PLA fibers

Structural support

Biomaterials for cardiovascular tissue engineering

[45]

Culture human coronary artery smooth muscle cells

(HCASMC)

Polyethylene Glycol (PEG)

Mix

3D Hydrogels

Neurites outgrowth

Biomaterials for peripheral nerve regeneration

[46]

Culture dorsal root ganglion (DRG) cells

Control cells invasion characteristics

Polypropylene fumarate/ tricalcium phosphate (PPF/TCP)

Mold method for PPF/TCP, scaffolds,

Porous cylinder structure

Bone growth

Biomaterials for Bone tissue engineering

[47]

Fibrin hydrogels were pipetted into the scaffolds

Culture human gingival fibroblasts (HGFs)

Multiwall carbon nanotube/polyurethane (MWCNT/PU)

Electrospinning for MWCNT/PU fiber, fiber fragments were incorporated into hydrogels

3D hydrogels with porous structure,

Conductivity,

Promote spinal cord regeneration

[48]

Culture endometrial stem cells (hEnSCs)

Hydrophilicity,

Hydrogels stiffness,

Reduced degradation rate

Cell adhesion and proliferation