Skip to main content
Fig. 7 | Journal of Biological Engineering

Fig. 7

From: Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo

Fig. 7

Results of immunohistochemical analysis, quantification of micro-vessel density and H&E staining. MMP9 expression was significantly decreased in mice receiving bacteria bearing construct at concentrations equal to 108 cfu/g compared to the PBS receiving group. Similarly, expression of VEGFR2 and Ki-67 was also significantly declined at the end of treatment period. Also, quantification of micro-vessel density by the CD31 marker in hot spots of sections demonstrated a significant decline in mice receiving 108 cfu bacteria bearing construct per gram of the body weight compare to the control group. Finally, the number of TILs and CD8+ TILs were significantly increased in mice treated with bacteria bearing construct at concentration equal to 108 cfu/g compared to the control group

Back to article page

Journal of Biological Engineering

ISSN: 1754-1611