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Fig. 3 | Journal of Biological Engineering

Fig. 3

From: Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds

Fig. 3

The stabilities of h8B-BsAb-WT, h8B-BsAb-2 A, h8B-BsAb-4 and h8B-BsAb. (A) the aggregation tendency of BsAbs was tested by turbidity assay. Antibodies were vortexed for up to 168 h at 25ºC and recording the absorbance (595nm) at various time points. (B) Antibodies without (0 h) or with a vortex (168 h) were analyzed by non-reducing SDS-PAGE. The red dotted line indicated the degradation of BsAbs. (C) The thermostability of BsAbs was measured by differential scanning calorimetry

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Journal of Biological Engineering

ISSN: 1754-1611