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Table 2 Binding affinity of BsAbs to antigens. Mean ± SD (n = 3)

From: Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds

Antibody

h8B-BsAb-WT

h8B-BsAb-2 A

h8B-BsAb-4

h8B-BsAb

Glypican-3 (nM)

1. 9 ± 0.1

2.4 ± 0.1

3.2 ± 0.3

2.2 ± 0.1

CD3 (nM)

48.4 ± 6.2

42.1 ± 3.6

52.9 ± 5.4

85.3 ± 7.0

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Journal of Biological Engineering

ISSN: 1754-1611