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Table 3 Binding affinity of BsAbs. Mean ± SD (n = 3)

From: Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds

a. Affinity of CEA-mAb and BsAbs to antigens. CEA: carcinoembryonic antigen.

Antibody

Affinity (nM)

 

Binding to CEA

Binding to CD3

CEA -mAb

4.7±0.3

-

CEA -BsAb

2.3±0.4

50.7±7.4

CEA -BsAb-WT

4.6±0.1

97.1±5.2

b. Affinity of h2E-mAb and BsAbs to antigens.

Antibody

Affinity (nM)

 

Binding to Glypican-3

Binding to CD3

h2E-mAb

47.0±4.1

-

h2E-BsAb

80.5±7.6

49.3±2.3

h2E-BsAb-WT

64.2±5.5

25.1±9.7