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Fig. 7 | Journal of Biological Engineering

Fig. 7

From: Fabricating a robust POSS-PCL nanofiber scaffold for nesting of mesenchymal stem cells: potential application in bone tissue regeneration

Fig. 7

The mRNA profile of differentiation genes, apoptosis gene, antioxidant gene, and VEGF angiogenesis factor. the scaffolds must protect the cells from oxidative stress and apoptosis when injected into the harsh condition of damaged tissues and then, the cells must have a bio-functional role in secretome or differentiation. As the molecular studies show the upregulation of antioxidants gene, Nrf2, angiogenesis gene, BAX, and differentiation genes, including RUNX2 and Osteocalcin. No toxicity was observed in the POSS-PCL scaffold and BAX as the pro-apoptosis gene was downregulated. Data display the mean values ± SD of at minimum 3 autonomous experiments. **; Statistical significance (P <0.01) compared to the control (Ctrl)

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Journal of Biological Engineering

ISSN: 1754-1611