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  1. This study aimed to analyze the growth of two types of blood vessel building cells: endothelial cells (ECs) and smooth muscle cells (SMCs) on surfaces with different morphology. Two types of materials, differi...

    Authors: Iwona Łopianiak, Michał Wojasiński, Aleksandra Kuźmińska, Paulina Trzaskowska and Beata A. Butruk-Raszeja
    Citation: Journal of Biological Engineering 2021 15:27
  2. Since autologous veins are unavailable when needed in more than 20% of cases in vascular surgery, the production of personalized biological vascular grafts for implantation has become crucial. Surface modifica...

    Authors: Eriselda Keshi, Peter Tang, Marie Weinhart, Hannah Everwien, Simon Moosburner, Nicolai Seiffert, Michael Lommel, Ulrich Kertzscher, Brigitta Globke, Anja Reutzel-Selke, Benjamin Strücker, Johann Pratschke, Igor Maximillian Sauer, Nils Haep and Karl Herbert Hillebrandt
    Citation: Journal of Biological Engineering 2021 15:26
  3. Cardiac hypertrophy is one of the most common genetic heart disorders and considered a risk factor for cardiac morbidity and mortality. The mammalian target of rapamycin (mTOR) pathway plays a key regulatory f...

    Authors: Byung-Hyun Cha, Minjin Jung, Angela S. Kim, Victoria C. Lepak, Brett A. Colson, David A. Bull and Youngwook Won
    Citation: Journal of Biological Engineering 2021 15:24
  4. The physiologic regenerative capacity of cartilage is severely limited. Current studies on the repair of osteochondral defects (OCDs) have mainly focused on the regeneration of cartilage tissues. The antler ca...

    Authors: Wenhui Chu, Gaowei Hu, Lin Peng, Wei Zhang and Zhe Ma
    Citation: Journal of Biological Engineering 2021 15:23
  5. T7 Expression System is a common method of ensuring tight control and high-level induced expression. However, this system can only work in some bacterial strains in which the T7 RNA Polymerase gene resides in the...

    Authors: Changchuan Ye, Xi Chen, Mengjie Yang, Xiangfang Zeng and Shiyan Qiao
    Citation: Journal of Biological Engineering 2021 15:22
  6. The development of an effective scaffold for bone defect repair is an urgent clinical need. However, it is challenging to design a scaffold with efficient osteoinduction and antimicrobial activity for regenera...

    Authors: Liu Zhongxing, Wu Shaohong, Li Jinlong, Zhang Limin, Wang Yuanzheng, Gao Haipeng and Cao Jian
    Citation: Journal of Biological Engineering 2021 15:21
  7. Development of engineered non-pathogenic bacteria, capable of expressing anti-cancer proteins under tumor-specific conditions, is an ideal approach for selectively eradicating proliferating cancer cells. Herei...

    Authors: Mitra Samadi, Keivan Majidzadeh-A, Malihe Salehi, Neda Jalili, Zeinab Noorinejad, Marjan Mosayebzadeh, Ahad Muhammadnejad, Azadeh Sharif khatibi, Shima Moradi-Kalbolandi and Leila Farahmand
    Citation: Journal of Biological Engineering 2021 15:20
  8. Ridge preservation is universally acknowledged as the conventional method for the post-extraction healing yet there are no standard materials for the ideal healing outcome. Herein, a composite gel comprising g...

    Authors: Shuai Yuan, Qingshu Li, Kaiwen Chen, Zhixiang Mu, Tao Chen, Huanan Wang and Ping Ji
    Citation: Journal of Biological Engineering 2021 15:19
  9. Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (Bs...

    Authors: Lin Yu, Nan Huang, Liangpeng Ge, Heng Sun, Yuna Fu, Chundong Liu and Jianhua Wang
    Citation: Journal of Biological Engineering 2021 15:18
  10. Skin wound healing is a complicated and lengthy process, which is influenced by multiple factors and need a suitable cellular micro-environment. For skin wound, wound dressings remain a cornerstone of dermatol...

    Authors: Chuan Fu, Zhiping Qi, Chengliang Zhao, Weijian Kong, Hongru Li, Wenlai Guo and Xiaoyu Yang
    Citation: Journal of Biological Engineering 2021 15:17
  11. Many patients suffering from peripheral arterial disease (PAD) are dependent on bypass surgery. However, in some patients no suitable replacements (i.e. autologous or prosthetic bypass grafts) are available. A...

    Authors: Nicolai Seiffert, Peter Tang, Eriselda Keshi, Anja Reutzel-Selke, Simon Moosburner, Hannah Everwien, Dag Wulsten, Hendrik Napierala, Johann Pratschke, Igor M. Sauer, Karl H. Hillebrandt and Benjamin Struecker
    Citation: Journal of Biological Engineering 2021 15:15
  12. A small scale stirred bioreactor was designed and the effect of different agitation rates (30, 60 and 100 rpm) was investigated on HepG2 cells cultured in alginate-chitosan (AC) core-shell microcapsule in term...

    Authors: Shahla Khodabakhshaghdam, Ali Baradar Khoshfetrat and Reza Rahbarghazi
    Citation: Journal of Biological Engineering 2021 15:14
  13. Bioreactors are essential tools for the development of efficient and high-quality cell therapy products. However, their application is far from full potential, holding several challenges when reconciling the c...

    Authors: Oscar Fabian Garcia-Aponte, Christoph Herwig and Bence Kozma
    Citation: Journal of Biological Engineering 2021 15:13
  14. The healing of large critical-sized bone defects remains a clinical challenge in modern orthopedic medicine. The current gold standard for treating critical-sized bone defects is autologous bone graft; however...

    Authors: Yonghyun Gwon, Sunho Park, Woochan Kim, Taeseong Han, Hyoseong Kim and Jangho Kim
    Citation: Journal of Biological Engineering 2021 15:12
  15. Synthetic biological circuits are widely utilized to control microbial cell functions. Natural and synthetic riboswitches are attractive sensor modules for use in synthetic biology applications. However, tunin...

    Authors: Yunhee Hwang, Seong Gyeong Kim, Sungho Jang, Jongmin Kim and Gyoo Yeol Jung
    Citation: Journal of Biological Engineering 2021 15:11
  16. In this review, we discuss violacein and prodigiosin, two chromogenic bacterial secondary metabolites that have diverse biological activities. Although both compounds were “discovered” more than seven decades ...

    Authors: Seong Yeol Choi, Sungbin Lim, Kyoung-hye Yoon, Jin I. Lee and Robert J. Mitchell
    Citation: Journal of Biological Engineering 2021 15:10
  17. Short-chain fatty acids, especially butyrate, play beneficial roles in sustaining gastrointestinal health. However, due to limitations associated with direct consumption of butyrate, there has been interest in...

    Authors: Dah Hyun Jung, Ji Hyun Yong, Wontae Hwang, Mi Young Yoon and Sang Sun Yoon
    Citation: Journal of Biological Engineering 2021 15:9
  18. In this literature review, the antipathogenic properties and contact-mediated antibacterial and antiviral performance of copper cold spray surfaces are assessed and compared with alternative antimicrobial mate...

    Authors: Bryer C. Sousa, Christopher J. Massar, Matthew A. Gleason and Danielle L. Cote
    Citation: Journal of Biological Engineering 2021 15:8
  19. Escherichia coli is a widely used platform for metabolic engineering due to its fast growth and well-established engineering techniques. However, there has been a demand for faster-growing E. coli for higher prod...

    Authors: Phuong N. L. VO, Hyang-Mi LEE, Jun REN and Dokyun NA
    Citation: Journal of Biological Engineering 2021 15:7
  20. The goal of the present study was to create a new biodegradable hybrid PCL-P (HEMA-NIPAAm) thermosensitive hydrogel scaffold by grafting PNIPAAm-based copolymers with biodegradable polyesters to promote the ch...

    Authors: Fereshteh Valipour, Farzaneh Valipour, Reza Rahbarghazi, Amir Mohammad Navali, Mohammad Reza Rashidi and Soodabeh Davaran
    Citation: Journal of Biological Engineering 2021 15:6
  21. Synthetic biomaterials assist in modulating the vascular response in an injured bone by serving as delivery vehicles of pro-angiogenic molecules to the site of injury or by serving as mimetic platforms which o...

    Authors: Wei He, Daixu Wei, Jun Zhang, Xiaonan Huang, Da He, Bo Liu, Qilong Wang, Mingming Liu, Ling Liu, Yajun Liu and Wei Tian
    Citation: Journal of Biological Engineering 2021 15:5
  22. Recognition proteins are critical in many biotechnology applications and would be even more useful if their binding could be regulated. The current gold standard for recognition molecules, antibodies, lacks co...

    Authors: Shivani Gupta Ludwig, Casey L. Kiyohara, Laura A. Carlucci, Dagmara Kisiela, Evgeni V. Sokurenko and Wendy Evelyn Thomas
    Citation: Journal of Biological Engineering 2021 15:3
  23. In this study, we constructed recombinant luminescent Escherichia coli with T7, T3, and SP6 promoters inserted between tol and lux genes as toluene biosensors and evaluated their sensitivity, selectivity, and spe...

    Authors: Guey-Horng Wang, Teh-Hua Tsai, Chun-Chi Kui, Chiu-Yu Cheng, Tzu-Ling Huang and Ying-Chien Chung
    Citation: Journal of Biological Engineering 2021 15:2
  24. Bioactive ceramics are promising candidates as 3D porous substrates for bone repair in bone regenerative medicine. However, they are often inefficient in clinical applications due to mismatching mechanical pro...

    Authors: Yifan Li, Ronghuan Wu, Li Yu, Miaoda Shen, Xiaoquan Ding, Fengling Lu, Mengtao Liu, Xianyan Yang, Zhongru Gou and Sanzhong Xu
    Citation: Journal of Biological Engineering 2021 15:1
  25. The stem cells of human exfoliated deciduous teeth (SHEDs) are considered to be one of the main sources of seed cells in stem cell therapy. The aim of this study was to examine the effect of ciliary neurotroph...

    Authors: Sujuan Zeng, Xuedan Zhao, Lingling Zhang, Janak L. Pathak, Wenyan Huang, Yunyang Li, Hongbing Guan, Wanghong Zhao, Lihong Ge and Yan Shu
    Citation: Journal of Biological Engineering 2020 14:29
  26. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yingying Xu, Hao Meng, Jie Ren and An-Ping Zeng
    Citation: Journal of Biological Engineering 2020 14:28

    The original article was published in Journal of Biological Engineering 2020 14:15

  27. Hybrid fibrous mat containing cell interactive molecules offers the ability to deliver the cells and drugs in wound bed, which will help to achieve a high therapeutic treatment. In this study, a co-electrospun...

    Authors: Afshin Fathi, Mehdi Khanmohammadi, Arash Goodarzi, Lale Foroutani, Zahra Taherian Mobarakeh, Jamileh Saremi, Zohreh Arabpour and Jafar Ai
    Citation: Journal of Biological Engineering 2020 14:27
  28. Undergraduate biomedical engineering (BME) students interested in pursuing a career in research and development of medical or physiological monitoring devices require a strong foundation in biosignal analysis ...

    Authors: Karly S. Franz, Kramay Patel and Dawn M. Kilkenny
    Citation: Journal of Biological Engineering 2020 14:26
  29. Nerve guidance conduits (NGCs) have emerged from recent advances within tissue engineering as a promising alternative to autografts for peripheral nerve repair. NGCs are tubular structures with engineered biom...

    Authors: Caleb E. Stewart, Chin Fung Kelvin Kan, Brody R. Stewart, Henry W. Sanicola III, Jangwook P. Jung, Olawale A. R. Sulaiman and Dadong Wang
    Citation: Journal of Biological Engineering 2020 14:25
  30. Small-scale cultivation vessels, which allow fed-batch operation mode, become more and more important for fast and reliable early process development. Recently, the polymer-based feeding system was introduced ...

    Authors: Timm Keil, Barbara Dittrich, Clemens Lattermann and Jochen Büchs
    Citation: Journal of Biological Engineering 2020 14:24
  31. Current approach for diabetes treatment remained several adverse events varied from gastrointestinal to life-threatening symptoms. Regenerative therapy regarding Edmonton protocol has been facing serious limit...

    Authors: Suryo Kuncorojakti, Watchareewan Rodprasert, Supansa Yodmuang, Thanaphum Osathanon, Prasit Pavasant, Sayamon Srisuwatanasagul and Chenphop Sawangmake
    Citation: Journal of Biological Engineering 2020 14:23
  32. Traffic accidents, falls, and many other events may cause traumatic spinal cord injuries (SCIs), resulting in nerve cells and extracellular matrix loss in the spinal cord, along with blood loss, inflammation, ...

    Authors: Ziyuan Yu, Hongru Li, Peng Xia, Weijian Kong, Yuxin Chang, Chuan Fu, Kai Wang, Xiaoyu Yang and Zhiping Qi
    Citation: Journal of Biological Engineering 2020 14:22
  33. Whole-cell biosensors are a powerful and easy-to-use screening tool for the fast and sensitive detection of chemical compounds, such as antibiotics. β-Lactams still represent one of the most important antibiot...

    Authors: Nina Lautenschläger, Philipp F. Popp and Thorsten Mascher
    Citation: Journal of Biological Engineering 2020 14:21
  34. Mechanical stimuli play important roles on the growth, development, and behavior of tissue. A simple and novel paper-based in vitro tissue chip was developed that can deliver two types of mechanical stimuli—lo...

    Authors: Kattika Kaarj, Marianne Madias, Patarajarin Akarapipad, Soohee Cho and Jeong-Yeol Yoon
    Citation: Journal of Biological Engineering 2020 14:20
  35. Implantation failure remains an unsolved obstacle in reproductive medicine. Previous studies have indicated that estrogen responsiveness, specifically by estrogen receptor alpha (ERα), is crucial for proper im...

    Authors: Dganit Stern-Tal, Hanna Achache, Liora Jacobs Catane, Reuven Reich and Tali Tavor Re’em
    Citation: Journal of Biological Engineering 2020 14:18
  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Farhad Abasalizadeh, Sevil Vaghefi Moghaddam, Effat Alizadeh, Elahe Akbari, Elmira Kashani, Seyyed Mohammad Bagher Fazljou, Mohammadali Torbati and Abolfazl Akbarzadeh
    Citation: Journal of Biological Engineering 2020 14:17

    The original article was published in Journal of Biological Engineering 2020 14:8

  37. Human mesenchymal stem cells (hMSCs) are intensely researched for applications in cell therapeutics due to their unique properties, however, intrinsic therapeutic properties of hMSCs could be enhanced by genet...

    Authors: Tyler Kozisek, Andrew Hamann, Albert Nguyen, Michael Miller, Sarah Plautz and Angela K. Pannier
    Citation: Journal of Biological Engineering 2020 14:16
  38. Glycine cleavage system (GCS) occupies a key position in one-carbon (C1) metabolic pathway and receives great attention for the use of C1 carbons like formate and CO2 via synthetic biology. In this work, we demon...

    Authors: Yingying Xu, Hao Meng, Jie Ren and An-Ping Zeng
    Citation: Journal of Biological Engineering 2020 14:15

    The Correction to this article has been published in Journal of Biological Engineering 2020 14:28

  39. The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and f...

    Authors: Hongru Li, Su Pan, Peng Xia, Yuxin Chang, Chuan Fu, Weijian Kong, Ziyuan Yu, Kai Wang, Xiaoyu Yang and Zhiping Qi
    Citation: Journal of Biological Engineering 2020 14:14
  40. Choroidal neovascularization (CNV) is a major cause of blindness in patients with age-related macular degeneration. CNV is characterized by new blood vessel growth and subretinal fluid accumulation, which resu...

    Authors: Farhad Farjood, Amir Ahmadpour, Sassan Ostvar and Elizabeth Vargis
    Citation: Journal of Biological Engineering 2020 14:13
  41. Synthetic biology aims at engineering gene regulatory circuits to end with cells (re)programmed on purpose to implement novel functions or discover natural behaviors. However, one overlooked question is whethe...

    Authors: Roser Montagud-Martínez, Jordi Ventura, Rafael Ballesteros-Garrido, Arantxa Rosado and Guillermo Rodrigo
    Citation: Journal of Biological Engineering 2020 14:12
  42. Liver metabolites are used to diagnose disease and examine drugs in clinical pharmacokinetics. Therefore, development of an in vitro assay system that reproduces liver metabolite recovery would provide importa...

    Authors: Astia Rizki-Safitri, Marie Shinohara, Minoru Tanaka and Yasuyuki Sakai
    Citation: Journal of Biological Engineering 2020 14:11
  43. Low-magnitude mechanical stimulation (LMMS) may improve skeletal health. The objective of this research was to investigate the long-term residual effects of LMMS on bone health. 10-week old female mice were gi...

    Authors: Kyle A. Bodnyk, Kyle S. Kuchynsky, Megan Balgemann, Brooke Stephens and Richard T. Hart
    Citation: Journal of Biological Engineering 2020 14:9
  44. Hydrogels are a three-dimensional and crosslinked network of hydrophilic polymers. They can absorb a large amount of water or biological fluids, which leads to their swelling while maintaining their 3D structu...

    Authors: Farhad Abasalizadeh, Sevil Vaghefi Moghaddam, Effat Alizadeh, Elahe akbari, Elmira Kashani, Seyyed Mohammad Bagher Fazljou, Mohammadali Torbati and Abolfazl Akbarzadeh
    Citation: Journal of Biological Engineering 2020 14:8

    The Correction to this article has been published in Journal of Biological Engineering 2020 14:17

  45. In current cancer spheroid culturing methods, the transfer and histological processing of specimens grown in 96-well plates is a time consuming process. A centrifugal fluidic device was developed and tested fo...

    Authors: Warren Weisler, Samuel Miller, Shaphan Jernigan, Gregory Buckner and Matthew Bryant
    Citation: Journal of Biological Engineering 2020 14:7